REWINE PHARMACEUTICAL
Pantoprazole with Domperidone Capsules

Pantoprazole with Domperidone Capsules

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Pantoprazole with Domperidone Capsules

The combination of domperidone and pantoprazole is marketed by Rewine Pharmaceuticals.

Pharmacokinetics

Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.

Pantoprazole + Domperidone Adverse Reactions / Pantoprazole + Domperidone Side Effects

Pantoprazole: Diarrhoea, dizziness, pruritus, skin rashes, GIT infections; anaphylaxis, angioedema, chest pain, dyspnoea, erythema multiforme, gastroenteritis, hyperglycaemia, infection, Inj site reaction, jaundice, optic neuropathy, anterior ischaemia, pancreatitis, speech disorder. Domperidone: Headache, insomnia, nervousness, dizziness, thirst, lethargy, irritability, GI disturbances, hot flushes, mastalgia, galactorrhoea, gynaecomastia, menstrual irregularities, rash, pruritus, urticaria, stomatitis, conjunctivitis, urinary frequency, dysuria, oedema, palpitations, leg cramps, asthaenia, drug intolerance.

Special Precautions

Lactation. Pantoprazole: Not recommended in child <12 years. Long-term therapy may lead to bacterial overgrowth in the GIT. Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma.

Other Drug Interactions

Care should be exercised when domperidone is administered in combination with MAO inhibitors.

Dosage

Oral
Gastro-oesophageal reflux disease, Dyspepsia

Adult: Per tablet/capsule contains pantoprazole 40 mg and domperidone 10 mg: 1 tablet/capsule once daily.