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Pantoprazole with Domperidone Capsules

Pantoprazole with Domperidone Capsules
Pantoprazole with Domperidone Capsules
Product Code : 06
45-150 INR
Price And Quantity
Minimum Order Quantity :
100
Unit of Measure :
Box/Boxes
Price :
45-150 INR
Product Specifications
Application :
Used in the treatment of acidity, heartburn and stomach ulcers.
Formulations Type :
General Drugs
Formulations Form :
Capsules
Storage Instructions :
Dry Place
Product Description

Pantoprazole with Domperidone Capsules

The combination of domperidone and pantoprazole is marketed by Rewine Pharmaceuticals.

Pharmacokinetics

Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.

Pantoprazole + Domperidone Adverse Reactions / Pantoprazole + Domperidone Side Effects

Pantoprazole: Diarrhoea, dizziness, pruritus, skin rashes, GIT infections; anaphylaxis, angioedema, chest pain, dyspnoea, erythema multiforme, gastroenteritis, hyperglycaemia, infection, Inj site reaction, jaundice, optic neuropathy, anterior ischaemia, pancreatitis, speech disorder. Domperidone: Headache, insomnia, nervousness, dizziness, thirst, lethargy, irritability, GI disturbances, hot flushes, mastalgia, galactorrhoea, gynaecomastia, menstrual irregularities, rash, pruritus, urticaria, stomatitis, conjunctivitis, urinary frequency, dysuria, oedema, palpitations, leg cramps, asthaenia, drug intolerance.

Special Precautions

Lactation. Pantoprazole: Not recommended in child <12 years. Long-term therapy may lead to bacterial overgrowth in the GIT. Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma.

Other Drug Interactions

Care should be exercised when domperidone is administered in combination with MAO inhibitors.

Dosage

Oral
Gastro-oesophageal reflux disease, Dyspepsia

Adult: Per tablet/capsule contains pantoprazole 40 mg and domperidone 10 mg: 1 tablet/capsule once daily. 

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